SKIN BOOSTERS | BIOSTIMULATORS
1. Profhilo
Profhilo is an injectable skin booster made of very pure, high-concentration hyaluronic acid that hydrates skin from within and stimulates collagen and elastin production.
It treats skin laxity, dry skin, fine lines, and dullness, typically requiring two sessions four weeks apart for lasting, natural-looking, firmer skin.
Key Benefits & Features:
- Deep Hydration: High-concentration HA acts as an intense moisturizer, boosting radiance.
- Skin Remodelling: Stimulates 4 types of collagen and elastin to improve skin firmness and elasticity.
- Minimalist Technique: Uses the BAP (Bio Aesthetic Points) technique, with only 5 injection points per side of the face.
- Results: Provides a “no-filter” glow, reducing fine lines and sagging.
- Versatility: Suitable for the face, neck, decolletage, hands, and arms.
Treatment Details:
- Procedure: Two sessions are required, typically spaced 4 weeks apart.
- Downtime: Minimal; small, temporary, mosquito-bite-like, bumps (blebs) may appear at injection sites but usually subside within hours.
- Suitability: Ideal for individuals with skin dryness, dull skin, or with visible signs of aging such as fine lines or loss of skin elasticity.
2. Plenhyage XL STRONG
Plenhyage XL Strong is a high-concentration (2.5%) polynucleotide-based injectable gel designed for intensive skin bio-revitalization, structural repair, and collagen stimulation.
It can treats deep wrinkles, sagging skin, pigmentation and scarring on the face, neck, and body by stimulating fibroblast regeneration, improving elasticity, and providing deep hydration.
Key Aspects of Plenhyage XL Strong:
- Mechanism: Uses high molecular weight polynucleotides to regenerate damaged tissue, act as a free radical scavenger, and increase skin density.
- Areas Treated: Suitable for the face, neck, décolleté, hands, and body areas needing firming (e.g., abdomen, thighs, buttocks).
- Indications: Ideal for mature, sagging, pigmented or sun-damaged skin, as well as addressing stretch marks and deep acne scars.
- Treatment Protocol: Typically 3 sessions are recommended, spaced 4 weeks apart, with maintenance every year.
- Results: Provides a natural, youthful appearance by repairing skin at a cellular level rather than adding volume.
3. Rejuran Healer
– Rejuran Healer is a popular skin rejuvenation treatment, also called “Baby Skin Injection”.
Using polynucleotides (PN) derived from salmon DNA, it repairs damaged skin, stimulates collagen, and enhances elasticity, targeting fine lines, large pores, pigmentation, acne scars, and oil-moisture balance.
Key Benefits of Rejuran Healer:
- Deep Skin Regeneration: Repairs damaged tissue and improves elasticity.
- Anti-Aging: Reduces fine lines, pigmentation and fine wrinkles.
- Skin Improvement: Refines texture, reduces pore size, and balances sebum production.
- Scar Treatment: Effectively improves acne scars.
Treatment Details:
Duration: Often done in 4 weeks intervals for the first three sessions, with maintenance every 9-12 months.
Target Areas: Primarily the face and neck.
Suitable for most skin types, including sensitive skin.
Rejuran is highly regarded for its regenerative properties rather than just hydrating, making it a powerful tool for rebuilding skin thickness and health.
4. Juvelook
Juvelook is a Korean hybrid skin booster combining Poly-D, L-Lactic Acid (PDLLA) and Hyaluronic Acid (HA) to stimulate collagen production and provide skin hydration.
It is used to treat wrinkles, fine lines, acne scars, enlarged pores, and under-eye hollowness, offering natural, long-lasting rejuvenation.
Key Details About Juvelook:
- How it Works: PDLLA stimulates natural collagen growth, while HA offers skin hydration and a volumizing effect.
- Treatment Areas: Commonly used on the face, neck, décolletage, and under-eye area.
- Results & Duration: Results are progressive, with a typical treatment plan involving 3 sessions spaced a month apart, lasting for 12–18 months.
Benefits:
- Improved Skin Quality: Boosts elasticity, firmness, and hydration.
- Reduced Aging Signs: Smoothes fine lines and rejuvenates skin texture.
- Acne Scar Treatment: Effective in reducing atrophic acne scars.
5. Sculptra
Sculptra is an FDA-approved, injectable collagen stimulator containing poly-L-lactic acid (PLLA) that acts as a bio-activator to restore facial volume, improve skin texture, and reduce wrinkles.
Unlike fillers, it works gradually by stimulating natural collagen production to provide long-lasting, natural-looking results that can last up to two years.
How It Works:
- Collagen Stimulation: Sculptra works by stimulating natural collagen production, forming a framework that supports and maintains the skin’s inner structure.
- Long-Lasting Results: Results are not immediate but develop progressively over several months.
- Target Areas: Commonly used for facial volume loss, deep lines, creases, and folds.
Benefits and Usage:
- Natural Results: Because it acts as a biostimulator, the improvements look natural and not overfilled.
- Sessions: A typical treatment plan often involves 3 sessions with 1 month interval per session.
6. Radiesse
Radiesse is an FDA-approved dermal filler and biostimulator composed of calcium hydroxylapatite (CaHa) microspheres, designed to immediately reduce moderate-to-severe wrinkles/folds, lift skin, and stimulate natural collagen and elastin production for long-term rejuvenation.
It is commonly used for cheeks, nasolabial folds, temporal, jawline contouring, and hand rejuvenation, with results often lasting 18–24 months.
Key Features and Benefits:
- Dual Action: Provides immediate volume restoration while acting as a scaffold for long-term collagen and elastin stimulation.
- Natural Results: Composed of calcium-based microspheres suspended in a gel, it mimics natural tissue and provides a firmer look.
- Versatility: Treats facial wrinkles, facial volume loss, sagging skin, and aging skin.
Targeted Treatment Areas:
- Lower Face: Smooths nasolabial folds, marionette lines, and defines the jawline.
- Cheeks/Temples: Restores lost volume for a lifted, youthful appearance.
- Hands: Corrects volume loss, reducing the visibility of veins and tendons.
7. Aesthefill
AestheFill is an injectable, biodegradable, and biocompatible collagen biostimulator made from Poly-DL-Lactic Acid (PDLLA), designed to restore facial volume, improve skin elasticity, and reduce wrinkles.
It works by stimulating the body’s natural collagen production in the deep dermis, providing gradual, natural-looking results that can last up to 2 years.
Key Aspects of AestheFill:
- Mechanism: Uses porous microspheres to stimulate collagen regeneration and fibroblast growth.
- Treatment Areas: Commonly used for sagging cheeks, temples, nasolabial folds, and skin rejuvenation on the face and neck.
- Results: Results are long-lasting (up to 2 years) and build gradually over several weeks to months.
- Procedure: Typically, 2 to 3 sessions are recommended, spaced 4 to 6 weeks apart, with minimal downtime.
- Safety: FDA-approved substance, generally safe with minimal side effects like swelling or bruising.
Key Benefits:
- Natural Volume Enhancement: Replaces lost collagen for a youthful appearance.
- Skin Tightening: Improves skin firmness and reduces wrinkles.
8. Nucleofill
Nucleofill is a polynucleotide-based (PN) bio-stimulator injectable used for deep skin rejuvenation, hydration, and lifting without adding volume.
It works by stimulating fibroblast activity to regenerate skin, improve elasticity, and reduce wrinkles, with popular applications for the face and under-eye areas.
Typically, 3 sessions are recommended for optimal results.
Key Aspects of Nucleofill Treatment:
- How it Works: Unlike traditional dermal fillers, Nucleofill uses natural, highly purified polynucleotides to stimulate skin cells for regeneration, deep hydration, and tissue firming.
- Benefits: It provides skin hydration, antioxidant effects, and a natural lifting effect by restructuring tissues.
- Suitability: It is ideal for patients with dehydrated, pigmented, acne scars or sagging skin looking for a natural, rejuvenated appearance
9. Exomide
Exomide is a bio-engineered exosome therapy designed for advanced skin rejuvenation and scalp hair loss treatment.
Using nano-vesicle technology, it delivers growth factors, proteins, and RNA to regenerate cells, improve skin elasticity, reduce wrinkles, and stimulate hair follicle growth. It is often used with microneedling.
Key Aspects of Exomide Exosome Therapy:
- Skin Rejuvenation (Exomide Ampoule): Promotes fibroblast repair, reduces inflammation, boosts collagen/HA expression, and treats pigment issues.
- Scalp Treatment (Exomide Scalp): Targets thinning hair and scalp rejuvenation by supporting hair follicle regeneration.
- Technology: Contains high-performance exosomes (including milk-derived options) to stimulate cellular communication and accelerate repair.
- Application: often paired with procedures like microneedling, fractional Co2 laser or injection methods to enhance absorption.
- Results: Patients often report glowing skin, tighter skin, fewer fine lines, and improved hair density.
Key Benefits:
- Rejuvenation: Firms sagging areas minimizes wrinkles, reduce acne scars and improve pigmentation.
- Repair: Restores damaged skin barriers and improves skin texture and skin quality.
- Growth: Promotes hair density, hair growth and healthy scalp.
10. Plinest
Plinest is a premium, injectable regenerative skin booster utilizing Highly Purified Technology (PN-HPT™) polynucleotides derived from trout DNA to repair, rejuvenate, and firm the skin at a cellular level.
It acts as a bio-revitalizing treatment, stimulating fibroblasts and collagen to reduce wrinkles, improve skin elasticity, dull skin, treat pigmentation, scars or hair loss.
Key Aspects of Plinest:
- Mechanism: Stimulates collagen, elastin, and fibroblasts, fostering deep tissue regeneration rather than just providing volume.
- Targeted Areas: Effective on the face, neck, scalp, and delicate areas like under-eyes.
- Key Benefits: Improves skin hydration, improves sagging skin, reduces pigmentation, acne scars/pores, and increases skin density.
Treatment Type: A minimally invasive, injectable, medical-grade treatment often requiring 3 sessions for long-lasting results.
11. Electri
Hyalual Electri is an injectable skin booster based on non-crosslinked hyaluronic acid and succinic acid, designed for intensive skin restoration, hydration, and brightening.
It suitable for face or under-eye area. It treats dark circles, dullness, and fine lines with minimal downtime and good results.
Key Benefits of Electri Skin Booster:
- Targeted Eye Rejuvenation: Specifically designed to treat “panda eyes” (dark circles), under-eye puffiness, and fine lines.
- Hydration & Glow: Combines hyaluronic acid for moisture with succinic acid to improve skin microcirculation.
- Results: 3 sessions with 1 month apart. However, noticeable results even single session.
Protocols :
- Anti-Aging & Antioxidant: Fights free radicals, reduces pigmentation, and improves skin texture and firmness.
- – Versatility: Suitable for treating dull, tired skin on the face, neck, and delicate areas like under-eyes or even underarms.
Key Ingredients & Mechanism:
- Hyaluronic Acid (0.55%): Delivers intense hydration.
- Succinic Acid: Acts as an antioxidant, boosts cellular metabolism, and enhances skin cell regeneration.
12. NCTF
NCTF Skin Booster (often called the “Chanel Injection”) is a premium, injectable treatment by Fillmed Laboratories, designed to hydrate, rejuvenate, and revitalize the skin.
It uses a blend of over 50 active ingredients—including hyaluronic acid, vitamins, amino acids, and antioxidants—to improve texture, increase elasticity, and boost radiance.
Key Benefits of NCTF Skin Booster:
- Purpose: Addresses dullness, dehydration, fine lines, and uneven texture.
- Components: Contains Hyaluronic Acid (HA) for moisture, along with vitamins, amino acids, and antioxidants to stimulate collagen and improve skin quality.
- Target Areas: Commonly used on the face, neck, décolletage, and hands.
- Procedure: A series of micro-injections administered by qualified practitioners, often involving little to no downtime.
- Session Structure: Optimal results often require 2–3 sessions, typically spaced every two to three weeks, with results lasting around 6 months.
Benefits and Side Effects:
- Benefits: Noticeably improved hydration, increased radiance, and a “glow” typically within a week of injection. It helps restore elasticity, reduces fine lines, and enhances overall skin vitality.
13. Ellanse
Ellansé is a unique, long-lasting dermal filler and collagen stimulator that provides immediate volume while stimulating the body’s natural collagen production for rejuvenated, firmer skin.
Composed of Polycaprolactone (PCL) microspheres in a carboxymethylcellulose (CMC) gel, it treats wrinkles, sagging, and volume loss, and also stimulate skin natural collagens typically lasting few years.
Key Aspects of Ellansé:
- Dual Action: It offers immediate filling (volume) and long-term rejuvenation by stimulating natural collagen synthesis.
- Areas Treated: Commonly used for Nasolabial folds, sunken cheeks, temples, jawline contouring, forehead, and aging hands.
- Longevity: Known as a long-lasting filler, results can last between 2 and 4 years depending individuals.
- Safety: FDA-approved and biocompatible.
- Results: Provides a natural-looking lift and improved skin quality over time, with results becoming more pronounced as new collagen is formed.
- Process: The treatment is non-surgical, with minimal to no downtime.
Ellansé is often favored for its ability to produce long-lasting, natural-looking results, making it popular in aesthetic clinics for facial rejuvenation and treatment for face volume loss.
14. Karisma
Karisma is an injectable, biocompatible skin booster that stimulates natural collagen production using Type I collagen and hyaluronic acid to firm, hydrate, and lift aging skin.
It addresses wrinkles and loss of volume in the face, neck, and hands, delivering improvements that last up to 12 months.
Key Benefits of Karisma Skin Booster:
- Composition: Contains recombinant human (Rh) collagen, high molecular weight hyaluronic acid, and carboxymethyl cellulose (CMC).
- Key Benefits: Improves skin density and elasticity, stimulates collagen synthesis, provides long lasting hydration, and softens fine lines or scars.
- Target Areas: Primarily used for the lower face, jawline, cheeks, neck, décolletage, and hands.
- Treatment Protocol: Typically 3 sessions are recommended, spaced 1 month apart, with results lasting 12 months depending on skin type and lifestyle.
- Safety: The formula is 100% natural, hypoallergenic, and free from chemical binders, boasting a 99.9% compatibility with human skin.
Karisma works by revitalizing the skin’s natural regenerative abilities, making it a popular choice for treating signs of aging without using traditional fillers
15. Revok50
Revok50 is a high-concentration, Italian-made injectable skin booster combining 50mg of stabilized hyaluronic acid (2,200 kDa) with amino acids (L-proline, L-hydroxyproline, glycine, L-lysine) to treat dehydration, fine lines, and aging.
It repairs connective tissue and boosts collagen production, lasting around 12 months depends on individuals.
Key Details of Revok50:
- Composition: Contains 50mg of hyaluronic acid and 195mg of amino acids, which is 2.5 times higher concentration than many competitive products.
- Mechanism: Uses a high molecular weight HA to provide intense hydration, while the amino acids specifically stimulate fibroblasts for collagen repair.
- Benefits: Deeply hydrates, improves elasticity, reduces fine lines and wrinkles, and enhances skin texture.
- Treatment Area: Suitable for face, neck, and hands.
- Procedure: It is a quick injection procedure. A typical protocol involves 3 sessions at 4-week intervals, though many notice improvements after the first session.
16. Luhilo
Luhilo Skin Booster is an injectable treatment designed for hydration, skin rejuvenation, and brightening effect.
It uses a combination of high and low molecular weight hyaluronic acid, amino acids, and peptides to improve elasticity, refine texture, and boost collagen production.
Key Benefits of Luhilo Skin Booster:
- Hydration: moisturizes skin, targeting dryness and dullness.
- Collagen & Elasticity Boost: Stimulates natural collagen and elastin production for a firmer look.
- Skin Rejuvenation: Reduces fine lines, shrinks pores, and improves skin texture.
- Glowing & Brightening: Enhances skin luminosity for a brighten and glowing skin.
How It Works:
- Luhilo is typically administered via injections to deliver nutrients (16 amino acids, 7 peptides)directly into the skin.
- It acts as a bio-restorer, not a traditional filler, focusing on skin quality rather than adding volume. It is suitable for those seeking a rejuvenated, brighter, and healthier complexion.
17. Gouri
GOURI is the world’s first fully liquid Polycaprolactone (PCL) injectable skin booster, designed to fundamentally reverse aging by stimulating natural collagen synthesis.
It spreads naturally across the face to enhance elasticity, tighten skin, and reduce wrinkles without creating artificial volume, offering a “filler-free” lifting effect.
Key Aspects of GOURI Skin Booster:
- Mechanism & Benefits: Unlike traditional fillers that fill space, GOURI is a collagen biostimulator that reverses collagen loss. It boosts skin quality, texture, and tone, resulting in a tighter, lifted appearance.
- Composition: It uses a fully solubilized biodegradable PCL polymer, which avoids the risk of complications associated with micro-particles found in other fillers.
- Treatment Protocol: A typical regimen involves 3 sessions, spaced 4 weeks apart, with initial visible results appearing 1-2 weeks post-treatment.
- Target Areas & Suitability: Suitable for the face, including areas around the eyes, cheeks, and mouth, for individuals experiencing early to moderate aging (20s–50s).
- Duration: The results can last between around 1 year.
18. Duesaderm
Deusaderm Lido is a next-generation injectable collagen biostimulator and dermal filler designed to treat wrinkles, sagging skin, and volume loss, particularly under-eye dark circles and tear troughs.
It uses purified Type I SPF porcine collagen to provide immediate volume while stimulating natural collagen production for long-lasting rejuvenation, often lasting up to 12 months.
Key Details About Deusaderm Lido:
- Purpose: Addresses fine lines, dark eye circles, skin laxity, and dullness.
- Mechanism: Acts as both a filler (immediate results) and a biostimulator (promotes long-term collagen growth).
- Composition: Contains highly purified Type I collagen with lidocaine for improved comfort, designed to match human skin collagen.
- Key Benefits: Provides natural-looking results without the bluish tint (Tyndall effect) or excessive water retention sometimes associated with hyaluronic acid fillers.
- Ideal For: Periorbital rejuvenation (treating “panda eyes”), lifting, and improving skin elasticity.
19. Linerase
Linerase is an Italian-made, CE-approved, injectable Heterologous Type I Collagen (HTIC) biostimulator designed to regenerate, firm, and rejuvenate aging or damaged skin.
It stimulates fibroblasts to produce new collagen, improving elasticity and reducing fine lines, wrinkles, acne scars, and stretch marks on the face, neck, and hands without adding excessive volume.
Results are natural-looking, with minimal downtime.
Key Aspects of Linerase Collagen Injection:
- How it Works: Unlike fillers that add immediate volume, Linerase is a bioregenerator that repairs the skin matrix from within, boosting natural collagen production.
- Target Areas: Suitable for the face, neck, décolletage, hands, and areas with scars or stretch marks.
- Ideal Candidates: Men and women with early-to-moderate signs of aging, particularly those with thin, saggy, pigmented or acne scar skin.
- Results & Maintenance: Results typically appear gradually over several weeks. A series of sessions is usually recommended for optimal, long-lasting rejuvenation.
Linerase is effective for treating skin laxity, atrophic scars, and early signs of hair thinning. It can also be combined with other treatments like lasers for enhanced results.
